CARDIOVASCULAR RISK ACCORDING TO THE FRAMINGHAM SCORE AND ITS ASSOCIATION WITH SOCIODEMOGRAPHIC, CLINICAL, BIOCHEMICAL, AND NUTRITIONAL VARIABLES IN ADULT PATIENTS WITH NON-ALCOHOLIC FATTY LIVER
CARDIOVASCULAR RISK ACCORDING TO FRAMINGHAM SCORE IN ADULT PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
DOI:
https://doi.org/10.17564/2316-3798.2026v10n2p193-208
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Abstract
This study aimed to assess the prevalence of cardiovascular risk (CVR) according to the Framingham Risk Score and its relationship with sociodemographic, clinical, biochemical, and nutritional variables in patients with Nonalcoholic Fatty Liver Disease (NAFLD) treated in outpatient clinics in Recife, Pernambuco, Brazil. This was a multicenter, cross-sectional, quantitative study, using a non-probabilistic convenience sample of 70 individuals of both sexes diagnosed with NAFLD. The sample exhibited a markedly elevated cardiometabolic risk profile, with a high prevalence of obesity (75.7%), increased waist circumference (95.71%), and low HDL-c levels (58.57%). Statistical analyses demonstrated that CVR, as determined by the Framingham Score, was significantly associated with the presence of Diabetes Mellitus and Systemic Arterial Hypertension (p < 0.05), as well as with the duration of NAFLD diagnosis (p < 0.05) and with LDL-c (p = 0.013) and Total Cholesterol levels (p = 0.020). Anthropometric variables such as Body Mass Index (BMI) and Waist Circumference (WC), despite their high prevalence of abnormalities, were not significantly associated with the Framingham Score. No associations were observed for sociodemographic variables; however, self-reported race showed a strong trend toward significance (p = 0.062), particularly among individuals identifying as Black, Brown, or Indigenous. The study concludes that clinical factors (hypertension and diabetes) and the duration of NAFLD diagnosis are more directly related to CVR according to the Framingham Score than isolated anthropometric parameters. These findings reinforce the close connection between NAFLD and metabolic disorders and highlight the importance of clinical and nutritional follow-up for these patients, with a primary focus on preventing cardiometabolic comorbidities.
