COMPARATIVE STUDY OF DIPYRONE VERSUS PARACETAMOL IN POST-EXTRACTION PAIN CONTROL
DOI:
https://doi.org/10.17564/2316-3798.2025v10n1p521-533
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Abstract
Pain is a complex sensory and emotional experience, often associated with tissue damage. In the dental context, effective pain management is essential, especially after surgical procedures that may lead to discomfort such as pain, inflammation, and edema. This study aimed to compare the effectiveness of dipyrone and paracetamol in controlling postoperative pain following minor oral surgeries.
A clinical trial was conducted at the Surgery Clinic of the Dentistry Course at UFPE. Patients underwent tooth extractions and were allocated into two groups: one received dipyrone and the other paracetamol, both co-administered with nimesulide. Pain was assessed using the Visual Analog Scale (VAS) every 6 hours for 72 hours. Statistical analysis was performed using the Mann-Whitney test.
The final sample consisted of 40 patients selected after initial screening. No cases of severe pain were observed in either group during the follow-up. Moderate pain was more frequent in the paracetamol group, especially during the first 24 hours. Conversely, mild pain was more common among those who received dipyrone, and the absence of pain was more frequently reported by patients who received paracetamol. The Mann-Whitney test did not identify statistically significant differences between the groups regarding pain relief during the evaluated periods (p > 0.05).
Previous studies suggest that dipyrone may be more effective in certain contexts, while paracetamol is widely used worldwide due to its favorable safety profile. The choice of analgesic should take into account not only efficacy but also safety and individual patient characteristics.
Dipyrone showed a trend toward better performance in managing mild pain, while paracetamol was more associated with moderate pain. However, no statistically significant differences were found between the two drugs in postoperative pain control after tooth extractions.
